Ranked by median pay, with jobs and rent share; from BLS and Census data.
Click any dot to open that city: jobs, pay, rent, commute, county economy and climate. Dot size follows population; colours follow the state flag.
By AtiveSite · Published 07/11/2026 · Updated 08/11/2026 · Every figure is linked to its source below.
10 metro areas in South Carolina publish pay for this occupation with at least 100 jobs, together 75,570 jobs. The three largest employers of registered nurses are Charlotte-Concord-Gastonia (27,010 jobs), Charleston-North Charleston (9,760 jobs), Greenville-Anderson-Greer (9,730 jobs), which hold 61.5% of those jobs. Median pay across these metros runs from $80,640 to $92,800 a year, against $82,360 for the whole state and $97,550 for the whole country.
BLS reports a national median of $97,550 a year for registered nurses (the lowest-paid tenth earn under $68,940 and the highest-paid tenth over $137,470). Employment is projected to change by +5.6% between 2025 and 2035, with about 180,800 openings a year including replacements. The typical entry route is: Bachelor's degree. Education requirements are BLS's typical ones, not legal rules; many states also license this work, so check the state board before applying.
Higher pay is not the whole story: look at the rent share column (yearly rent divided by median pay) and the price level (100 is the national average). A metro with a lower salary but cheaper housing can leave more money at the end of the month. The location quotient shows where the occupation is concentrated; employers cluster where it is above 1, which usually means more openings and more competition among employers for the same skills.
Registered nurses in South Carolina: the highest median pay is in the Charleston-North Charleston, SC area ($92,800 a year); the most jobs are in the Charlotte-Concord-Gastonia, NC-SC area (27,010). Statewide the median is $82,360 with 49,750 jobs. Metro areas with at least 100 jobs in this occupation are listed; click a column to sort.
| Metropolitan area ⇅ | Jobs ⇅ | Median pay ⇅ | Entry (10th pct.) ⇅ | Top (90th pct.) ⇅ | Location quotient ⇅ | Yearly rent as % of median pay ⇅ | Price level (US = 100) ⇅ |
|---|---|---|---|---|---|---|---|
| Charleston-North Charleston, SC | 9,760 | $92,800 | $71,120 | $117,900 | 1.14 | 21% | 101.0 |
| Charlotte-Concord-Gastonia, NC-SC | 27,010 | $90,620 | $69,680 | $110,020 | 0.91 | 20% | 97.3 |
| Augusta-Richmond County, GA-SC | 6,880 | $87,760 | $69,760 | $116,640 | 1.36 | 15% | 91.9 |
| Sumter, SC | 670 | $86,260 | $66,830 | $104,660 | 0.89 | 15% | 88.0 |
| Spartanburg, SC | 4,440 | $82,360 | $70,180 | $101,420 | 1.24 | 15% | 91.1 |
| Columbia, SC | 9,400 | $81,920 | $68,460 | $108,210 | 1.10 | 17% | 93.7 |
| Greenville-Anderson-Greer, SC | 9,730 | $81,400 | $68,530 | $100,630 | 1.03 | 17% | 93.3 |
| Hilton Head Island-Bluffton-Port Royal, SC | 1,410 | $81,400 | $64,180 | $97,590 | 0.79 | 23% | 98.0 |
| Florence, SC | 3,120 | $81,170 | $65,710 | $174,900 | 1.61 | 14% | 86.8 |
| Myrtle Beach-Conway-North Myrtle Beach, SC | 3,150 | $80,640 | $66,250 | $100,380 | 0.99 | 19% | 93.6 |
National page: Registered nurses →Cities of South Carolina
Rent uses the metro median gross rent (ACS) and appears only for metros that contain a city of this guide. "n/a" means BLS suppressed the figure or we have no rent for that metro.
In the Charleston-North Charleston, SC area, with a median of $92,800 a year (BLS OEWS, May 2025; metro areas with at least 100 jobs).
In the Charlotte-Concord-Gastonia, NC-SC area, with 27,010 jobs.